Fixed drug eruption (FDE) is a common entity encountered in our day-to-day clinical practice.It is a T-cell-dependent pathway with induction of interferon-gamma-producing CD8+ PCA tees T-cells in the dermis and epidermis.It is not just a drug that causes a fixed eruption but has also been described with food known as fixed food Feminine Sanitary Supplies eruption and also with other agents.The article describes the common causes and pathomechanism of FDE.